April 23 2021
THE MOUSE PREFRONTAL CORTEX: UNITY IN DIVERSITY
In this Perspective in Neuron, Pierre Le Merre, Sofie Ährlund-Richter and Marie Carlén provide a new comprehensive view of structural and functional distinctions of the mouse prefrontal cortex (PFC) and emphasizes the relevance of studying the PFC as a whole to unravel the integrative cognitive functions of this brain region.
A research synthesis of 100 recent publications (2011-2020) utilizing in vivo perturbation of behavior is included, and the results question absolute localized functions in the PFC.
Analyzed large-scale connectivity data indicate that the PFC is a module, holding a few larger subdivisions defined by their whole-brain connectivity.
The Perspective also covers neuronal correlates to cognitive functions of the mouse PFC and cellular mechanisms underlying PFC feedback modulation of downstream regions.
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